A recent report from the Substance Abuse and Mental Health Services Administration (SAMHSA) called the opioid crisis among Hispanic/Latino* populations an “urgent issue,” and described the unique challenges faced by this population — including intergenerational and intercultural differences within households, language barriers, and stress related to migration and discrimination. As the fastest growing minority population in the U.S., it is imperative that the public health community better understand and address these challenges to not only curb the opioid epidemic but improve the overall health of Hispanic/Latinos across the country.